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Compared to IgG antibodies, IgMs do not bind well to protein A or G resins. IgM antibodies are sensitive to pH conditions and are soluble within narrow solubility ranges. Their large molecular size also reduces their diffusion constant relative to IgG. However, IgMs have high charge, making ion exchange (IEX) more suitable for their purification. High-purity IgM fragments can be obtained by controlling flow rates and adjusting salt concentrations.
Check more details: igm antibody production